Different antiulcer activities of pantoprazole in stress, alcohol and pylorus ligation-induced ulcer models. > 연구자료실

본문 바로가기

연구자료실

연구자료실
IP: ***.***.***.4.1

Different antiulcer activities of pantoprazole in stress, alcohol and …

페이지 정보

최고관리자 조회수 : 1,057

본문

Lab Anim Res. 2011 Mar;27(1):47-52. doi: 10.5625/lar.2011.27.1.47. Epub 2011 Mar 25.

Different antiulcer activities of pantoprazole in stress, alcohol and pylorus ligation-induced ulcer models.

Abstract

Antiulcer effects of pantoprazole, a proton-pump inhibitor, on water-immersion restraint stress (WIRS)-, alcohol (ethanol)- and pylorus ligation-induced gastric ulcers were investigated in male rats. Rats were orally administered with pantoprazole 30 min prior to exposure to various types of ulcer inducers. In stress-induced ulcer model, rats were subjected to WIRS at 22℃ for 4 hours, and the degree of ulcer (in mm) was evaluated. In alcohol-induced ulcer model, rats were orally administered with pure (100%) ethanol (1 mL/kg), and the ulcer lesions were measured 1 hour after ethanol challenge. In pylorus ligation-induced ulcer model, rats were subjected to pylorus ligation, and the degree of erosions and ulcers was scored 17 hours after the operation. Pantoprazole attenuated the ulcer lesions induced by WIRS in a dose-dependent manner, exhibiting a median effective dose (ED(50)) value of 0.78 mg/kg. By comparison, pantoprazole was effective at relatively-high doses for the improvement of ethanol-induced ulcers, showing an ED(50) value of 20.5 mg/kg. Notably, pantoprazole was practically ineffective (ED(50)>50.0) in pylorus ligation model. Taken together, it was confirmed that pantoprazole showed inhibitory activity on gastric ulcers induced by stress and alcohol, but was ineffective on pylorus ligation-induced ulcer. Therefore, the results indicate that proton-pump inhibitors including pantoprazole might reveal highly-different effects according to the type of ulcer inducers, and that the prescription of antiulcer agents should be carefully selected.

KEYWORDS:

Pantoprazole; alcohol; gastric ulcer; pylorus ligation; stress

연구자료실 목록
No 제목 이름 조회
2 최고관리자 1058
1 최고관리자 1063
대표 : 김좌진 ㅣ 개인정보관리 : 김좌진 ㅣ 사업자번호 : 253-86-01081 ㅣ 통신판매업신고: 2018-대전동구-0190호
본사 : 대전광역시 동구 충정로 21, 4105호 ㅣ 기업부설연구소 : 대전광역시 동구 충정로 21, 4104호
당사는 모든 이미지의 무단사용을 금하며, 무단사용시 저작권법 98조에 의거 민형사상 책임을 지게됩니다.
COPYRIGHT ©2019 (주)프로셀컴퍼니. ALL RIGHTS RESERVED.