Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease > NEWS

본문 바로가기

NEWS

NEWS
IP: ***.***.***.135

Noncanonical function of an autophagy protein prevents spontaneous Alz…

페이지 정보

최고관리자 조회수 : 1,375

본문

Abstract

Noncanonical functions of autophagy proteins have been implicated in neurodegenerative conditions, including Alzheimer’s disease (AD). The WD domain of the autophagy protein Atg16L is dispensable for canonical autophagy but required for its noncanonical functions. Two-year-old mice lacking this domain presented with robust β-amyloid (Aβ) pathology, tau hyperphosphorylation, reactive microgliosis, pervasive neurodegeneration, and severe behavioral and memory deficiencies, consistent with human disease. Mechanistically, we found this WD domain was required for the recycling of Aβ receptors in primary microglia. Pharmacologic suppression of neuroinflammation reversed established memory impairment and markers of disease pathology in this novel AD model. Therefore, loss of the Atg16L WD domain drives spontaneous AD in mice, and inhibition of neuroinflammation is a potential therapeutic approach for treating neurodegeneration and memory loss. A decline in expression of ATG16L in the brains of human patients with AD suggests the possibility that a similar mechanism may contribute in human disease.



https://advances.sciencemag.org/content/6/33/eabb9036?fbclid=IwAR1Lja74zDj3wnfUiZ9EdbaucrP0efQZrV8LXqgSLMu0wRKHuQOrPfmj2_A




NEWS 목록
No 제목 이름 조회
533 최고관리자 1340
532 최고관리자 1291
531 최고관리자 1330
530 최고관리자 1409
529 최고관리자 1314
528 최고관리자 1337
527 최고관리자 1380
526 최고관리자 1376
525 최고관리자 1400
524 최고관리자 1440
523 최고관리자 1371
522 최고관리자 1365
521 최고관리자 1352
520 최고관리자 1381
519 최고관리자 1397
대표 : 김좌진 ㅣ 개인정보관리 : 김좌진 ㅣ 사업자번호 : 253-86-01081 ㅣ 통신판매업신고: 2018-대전동구-0190호
본사 : 대전광역시 동구 충정로 21, 4105호 ㅣ 기업부설연구소 : 대전광역시 동구 충정로 21, 4104호
당사는 모든 이미지의 무단사용을 금하며, 무단사용시 저작권법 98조에 의거 민형사상 책임을 지게됩니다.
COPYRIGHT ©2019 (주)프로셀컴퍼니. ALL RIGHTS RESERVED.