논문: The MS4A gene cluster is a key modulator of soluble TREM2 and Alzh…
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논문 제목: The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
내용 요약:
[MS4A4A modulates sTREM2.]
- Common variants in the membrane-spanning 4-domains subfamily A (MS4A) gene region were associated with CSF sTREM2 concentrations.
- The single-nucleotide polymorphism rs1582763 modified expression of the MS4A4A and MS4A6Agenes in multiple tissues, suggesting that one or both of these genes are important for modulating sTREM2 production.
- MS4A4A and TREM2 colocalized on lipid rafts at the plasma membrane.
- sTREM2 increased with MS4A4A overexpression.
- Silencing of MS4A4A reduced sTREM2 production.
원문 출처:
https://stm.sciencemag.org/content/11/505/eaau2291?fbclid=IwAR0ikMexZDKQqS6ATNZ7A79nLHzhYR4ur0SGCpFVdhUHgz85SR_sVNVQwAI